BACTERIAL SPECTRUM IN EXACERBATION COPD PATIENTS.
- Microbiologist. MD. PhD.TSMU the First University Clinic (Tbilisi, Georgia).
- Head of Department of Internal Medicine. Professor. MD. PhD.TSMU the First University Clinic (Tbilisi, Georgia).
- Head of Clinical Laboratory. Professor. MD. PhD.TSMU the First University Clinic (Tbilisi, Georgia).
- Laborant Physician TSMU the First University Clinic (Tbilisi, Georgia).
- Abstract
- Keywords
- References
- Cite This Article as
- Corresponding Author
The precise role of bacterial infection in the course of exacerbation COPD has been a source of controversy for decades.Chronic bacterial colonization of the lower airways contributes to airway inflammation; The course of COPD is characterized by intermittent exacerbacions of the disease.Approximately 40-50% acute exarbations are caused by bacteria, by viruses in 25%, and both viruses and bacteria in another 25%. Airway inflammation is increased during the exacerbation resulting in increased hyperinflation, reduced expiratory air flow and decreased gas exchange. Expectorated sputum is the most commonly used sample for diagnosis of lower respiratory tract infections(LRTI),which can be obtained easily and non-invasively. The bacteria are very common in the lower respiratory tract of patients with COPD and cause inflammation. We have shown that among microorganisms causing acute exacerbations of COPD in our patients prevailed gram negative Enterobacteriaceae family and comparatively high resistance against cephalosporins and fluoroquinolones related to wide usage of antibiotics of this group for chemoprophilaxis.
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[Tamar Didbaridze, Kakhaber Chelidze, Nino Gogokhia and Khatia Mikaberidze. (2017); BACTERIAL SPECTRUM IN EXACERBATION COPD PATIENTS. Int. J. of Adv. Res. 5 (Mar). 2028-2030] (ISSN 2320-5407). www.journalijar.com
