18Feb 2017

THE GENETICS OF SYSTEMIC LUPUSERYTHEMATOSUSIN SAUDI ARABIA

  • Department of Pathology, School of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia.
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Systemic Lupus Erythematosus (SLE) is a complex multisystem autoimmune disorder. It is characterized by the production of autoantibodies that react against its own tissues, which may lead to immune-complex mediated end organ involvement. There are more than 30 genetic loci in different ethnic backgrounds that have been associated with the risk of developing this disease. The high level of consanguinityin the Saudi population is a risk factor for developing the disease. On the other hand, it provides an opportunity to identify the genetic variations that are associated with the disease. Applying Genome Wide Association Studies (GWAS) and exome sequencing would help to identify these variations. This review provides an opportunity to outline the genetics of Systemic Lupus Erythematosus in the Saudi population.

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[Rami Nassir. (2017); THE GENETICS OF SYSTEMIC LUPUSERYTHEMATOSUSIN SAUDI ARABIA Int. J. of Adv. Res. 5 (Feb). 524-529] (ISSN 2320-5407). www.journalijar.com

Rami Nassir
Assistant Professor in Medical Genetics, Pathology Dept., School of Medicine Umm Al-Qura University

DOI:

Article DOI: 10.21474/IJAR01/3181      
DOI URL: https://dx.doi.org/10.21474/IJAR01/3181

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