31Jan 2017

SEX DIFFERENCES IN TRACE METALS AND DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS.

  • Rheumatology Laboratory, Department of Biotechnology, Chhatrapati Shahu Ji Maharaj University, Kanpur.
  • Department of Biochemistry, Integral University, Lucknow.
  • Community Health Centre, Shivrajpur, Kanpur.
  • Department of Biotechnology, Baba Bhimrao Ambedkar University, Lucknow.
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Abstract Objectives: Rheumatoid arthritis (RA) is chronic autoimmune disease marked by tissue inflammation and joint destruction. Sex differences and essential element derangement in the incidences of RA are well described. Methods: The present study aims to determine serum mineral level, superoxide dismutase (SOD) activity and disease activity score (DAS) in female and male RA subjects and association of minerals with disease activity in both the sexes. Results: Female RA patients had significantly reduced serum Zn as compared to male RA subjects. Females had non significantly low values for copper, magnesium and phosphorous as compared to male RA subjects. SOD and DAS were significantly increased in female RA subjects. The RA subjects had higher levels of serum zinc, copper and lower levels of serum Mg when compared with reference values. However none of them were found to be associated with disease activity. Conclusions: The results suggest derangement of minerals in RA where mineral evaluation and supplementation especially of magnesium in RA patients would be helpful.

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[Vivek Kumar, Ajai Kumar, Jaya Prakash, Varsha Gupta and M Y Khan. (2017); SEX DIFFERENCES IN TRACE METALS AND DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS. Int. J. of Adv. Res. 5 (Jan). 2513-2518] (ISSN 2320-5407). www.journalijar.com

Varsha Gupta
Chhatrapati Shahu Ji Maharaj University, Kanpur

DOI:

Article DOI: 10.21474/IJAR01/3039      
DOI URL: https://dx.doi.org/10.21474/IJAR01/3039

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