20Jan 2017

EFFECT OF POMEGRANATE JUICE AND PEEL ON ANTIOXIDANT ENZYMES AND LIPID PROFILE IN CARBON TETRACHLORIDE-INDUCED HYPERLIPIDEMIC RATS.

  • Fellow of Nutrition, Medical Research Institute - University of Alexandria.
  • Assistant Professor of food analysis, High Institute of Public Health- University of Alexandria.
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Lipid peroxidation is a crucial step in the pathogenesis of free radical-related disease states, including glomerulonephritis, rheumatoid arthritis, gastrointestinal and cardiovascular diseases. Antioxidants play a significant role in protecting living organism from the toxic effect of various chemicals by preventing free radical formation. Pomegranate is a good source of polyphenols and other antioxidants. The purpose of the present study is to evaluate the effect of pomegranates juice and peel administration on antioxidant enzymes activities and lipid profile in carbon tetrachloride-induced hyperlipidemic rats. Hyperlipidemic rats were treated with pomegranates juice and peel for 8 weeks. Results showed that all hyperlipidemic rats administrated juice and peel had significant decrease in TBARS concentration and increase in GSH, GPx, GST, CAT and SOD in plasma compared to CCl4 group. Lipid profile parameters (except HDL-C) decreased significantly with juice and peel administration compared to CCl4 group. In conclusion, consumption of pomegranate juice and peel showed significant improvement of lipid parameters and antioxidant enzyme activities in hyperlipidemic rates suggesting therapeutic potential of using pomegranate as a medicinal plant for managing hyperlipidemia and modifying the risk of CVD.

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[Doaa M. Genena and Neveen F. Agamy. (2017); EFFECT OF POMEGRANATE JUICE AND PEEL ON ANTIOXIDANT ENZYMES AND LIPID PROFILE IN CARBON TETRACHLORIDE-INDUCED HYPERLIPIDEMIC RATS. Int. J. of Adv. Res. 5 (Jan). 1708-1714] (ISSN 2320-5407). www.journalijar.com

Doaa Mounir Genena
Medical Research Institute - University of Alexandria

DOI:

Article DOI: 10.21474/IJAR01/2941      
DOI URL: https://dx.doi.org/10.21474/IJAR01/2941

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