ESTIMATED AVERAGE GLUCOSE, EAG – A MORE INTUITIVE UNDERSTANDING OF GLYCEMIC CONTROL

Objective: Glycosylated hemoglobin (HbA1c) is considered as an index of glycemic status over the preceding 2-3 months. Because the HbA1c level is a marker of blood glucose for the previous 60–90 days, average blood glucose levels can be estimated using HbA1c levels. Our aim in the present study was to investigate the relationship between estimated average glucose (eAG) levels, as calculated by HbA1c levels, and fasting plasma glucose (FPG) levels. Methods: Retrospective analysis of 1000 patients in the Department of Biochemistry for FPG and HbA1c was done. The eAG levels were calculated using the following formula: (28.7 x HbA1c) – 46.7. FPG and HbA1c levels were determined using glucose oxidase-peroxidase method and turbidimetric inhibition immunoassay (TINIA), respectively. According to FPG levels, the patients were divided into Group A (FPG<126mg/dl), Group B (FPG 126-200 mg/dl) and Group C (FPG>200 mg/dl). Results: A strong positive correlation between FPG levels and eAG levels (r=0.83, p<0.0001) was observed. The difference was statistically significant. Conclusion: The discrepancy between HbA1c and blood glucose level units is problematic and confusing among patients. So we suggest, eAG which shows strong correlation with FPG, to be reported along with HbA1c. This will help promote positive patient outcomes, as well as enhance each individual’s understanding and ability to manage his or her diabetes more effectively.