31Dec 2016

A study of the effect of Nigella sativa (Black seeds) on pyrazinamide and anti-tuberculosis drugs induced hepatotoxicity in rabbits.

  • Assistant lecturer, B.Sc. Pharmacy, Department of Pharmacy, College of Medicine, University of Misan, Iraq.
  • Assistant Professor, MBChB, PhD, Department of Pharmacology, College of Medicine, University of Basrah, Iraq.
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Hepatotoxicity is a real challenge to physicians concerned intuberculosis treatment. It is frequently blamed for therapy failure and emergence of bacterial resistance and sometimes fatal. In the absence of a drug which can prevent hepatotoxicity, herbal medications offer an alternative remedy to minimize this side effect. The study was designed to evaluate the effect ofNigella sativa (NS), a medicinal plant known for its hepatoprotective effect against hepatotoxicity induced by Pyrazinamide (PZA) 350 mg/kg alone or in combination with other anti-tuberculosis drugs (anti-TB). Anti-TB drugs contain PZA 350 mg/kg + INH 50 mg/kg + Rifampicin (RIF) 100 mg/kg.Six groups of rabbits (6 animals in each) were treated orally for 12 days as follow: Normal saline (control), NS, PZA, (PZA+NS), (Anti-TB drugs), and (Anti-TB + NS). Liver enzymes, S. Glutathione (GSH), liver tissue (GSH) and Malondialdehyde (MDA) were estimated and liver histology was examined. PZA and anti-TB drugs increased liver enzymes, increased MDA and decreased GSH with histopathological changes suggestive of hepatotoxicity. Treatment with NS significantly changed liver enzymes, GSH, MDA and histopathological changes toward normal values. Conclusions: NS due to its antioxidant effect is protective against hepatotoxicity induced by PZA and anti-TB drugs.

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[Rasha K. Khudur and Jawad H. Ahmed. (2016); A study of the effect of Nigella sativa (Black seeds) on pyrazinamide and anti-tuberculosis drugs induced hepatotoxicity in rabbits. Int. J. of Adv. Res. 4 (Dec). 2836-2845] (ISSN 2320-5407). www.journalijar.com

Rasha kareem khudhur
pharmacist

DOI:

Article DOI: 10.21474/IJAR01/2711      
DOI URL: https://dx.doi.org/10.21474/IJAR01/2711

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