DETERMINATION OF PARACETAMOL AND KINETIC PARAMETERS USING NICKEL HEXACYANOFERRATE MODIFIED CARBON PASTE ELECTRODE.

Electrochemical response characteristics of modified carbon paste electrode towards detection and determination of paracetamol was investigated by cyclic voltammetric technique in 0.1 M acetate buffer solution containing 0.1 M KCl as supporting electrolyte. Nickel Hexacyanoferrate modified carbon paste electrode was developed by immobilizing different ratios of Nickel Hexacyanoferrate. The best ratio for kinetic parameter and paracetamol determination was 20% (w/w) NiHCF; 55% graphite and 25% (w/w) paraffin oil respectively. For the determination of paracetamol concentration, an accurate amount of 500 mg Paramol,Cadimol,Paracetamol and Panamol tablets were transferred to four different 100 ml volumetric flask and this volume completed with acetate buffer (pH 7.5).The percentage content or concentration of acetaminophen in these 500 mg paracetamol tablet samples were determined. The detection limit of the modified carbon paste electrode was 8.89 x 10-5 M for paracetamol. The relative standard deviations for the determination of paracetamol was less than 2.%.Transfer coefficient (?) and heterogeneous electron transfer rate constantk for catalytic reaction were found tobe 0.705 and 2.37 × 10-2s-1respectively.