CYTOGENETIC AND IMMUNOLOGIC STUDIES ON COUPLE EXPERIENCING BAD OBSTETRIC HISTORY

Bad obstetric history (BOH) is the common complication of pregnancy, affecting approximately 15% of all clinically recognized pregnancies in the general population. Majority of sporadic cases before 10 week of gestation are as a result of chromosomal anomalies. The overall frequency of BOH was estimated from 1% to 3%. BOH also referred as Recurrent pregnancy loss (RPL) or Recurrent miscarriages (RM) or Habitual abortion, because these are historically defined as 3 consecutive pregnancy losses prior to 20 weeks from the last menstrual period. Incidence of BOH was found to be 5.27%, including (1.4%) with history of unexplained stillbirth or neonatal loss. The causes of BOH may be genetic, hormonal, abnormal maternal immune response, and maternal infection. The present study was carried out in 30 couples suffering with bad obstetric history were selected as study subject. The cytogenetic analysis results were correlated with various demographic, clinical and lifestyle aspects of couples with BOH. Increasing maternal age, paternal age, duration of married life, number of gestations, number of abortions, infections and history of illness etc. can lead to chromosome abnormality. Identify any recurrent or non-recurrent causes of pregnancy loss and put in place a management plan to reduce or modify the risks in the current or future pregnancies.