CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF NSCLC AND VEGF GENE POLYMORPHISM.
Mikhail N. Shapetska
, Anna N. Shchayuk
, Elena P. Mikhalenko
, Natalia V. Chebotareva
, Svetlana N. Pisarchik
and Evelina V. Krupnova.
- Belarusian State Medical University, Minsk, Republic of Belarus.
- Institute of Genetics and Cytology NAS of Belarus, Minsk, Republic of Belarus,
- City Clinical Pathologoanatomic Bureau, Minsk, Republic of Belarus.
- Abstract
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Our study shown prognostic effect of VEGF gene polymorphisms on clinical features of NSCLC. As vascular endothelial growth factor (VEGF) is a major driver of angiogenesis and cancer cells proliferation, we evaluated survival the group of patients with NSCLC from the position of VEGF gene polymorphisms, TNM and histological types of tumor. Analysis revealed that polymorphisms VEGF gene influence the outcome of treatment, histological type, size, metastasis as aggressiveness of the NSCLC.
[Mikhail N. Shapetska, Anna N. Shchayuk, Elena P. Mikhalenko, Natalia V. Chebotareva, Svetlana N. Pisarchik and Evelina V. Krupnova. (2016); CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF NSCLC AND VEGF GENE POLYMORPHISM. Int. J. of Adv. Res. 4 (Sep). 1802-1813] (ISSN 2320-5407). www.journalijar.com
