FUNCTIONAL TESTING OF VITAMIN D RESPONSE ELEMENTS IN THE LCE2 GENE CLUSTER WITH RELEVANCE TO PSORIASIS.
- College of Medicine, Al Imam Muhammad Ibn Saud Islamic University, Riyadh, Saudi Arabia.
- Basic Medical Sciences,University of Arizona College of Medicine, Phoenix,Arizona,United States.
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Psoriasis is a chronic inflammatory skin disease characterized by abnormal keratinocyte proliferation and differentiation. A genetic risk factor for psoriasis is a deletion of LCE3B and LCE3C genes encoding structural proteins in terminally differentiated keratinocytes, suggesting that compromised skin barrier function has a role in psoriasis susceptibility. Because analogs of 1,25-dihydroxyvitamin D3 (1,25D) are used in psoriasis treatment, we hypothesized that 1,25D acts via the vitamin D receptor (VDR) to upregulate expression of LCE2B genes, potentially mitigating the absence of LCE3B/LCE3C gene products.
[Abdullah Aljabri, Abdullah Alhazmi, Osama Alateeq, G Kerr Whitfield and Jui-Cheng Hsieh. (2016); FUNCTIONAL TESTING OF VITAMIN D RESPONSE ELEMENTS IN THE LCE2 GENE CLUSTER WITH RELEVANCE TO PSORIASIS. Int. J. of Adv. Res. 4 (Sep). 1949-1951] (ISSN 2320-5407). www.journalijar.com
