APOLIPOPROTEIN B / A1 RATIO AS RISK PREDICTOR OF ANGIOGRAPHICALLY PROVEN ATHEROSCLEROSIS

Background:-Apolipoproteins B and A-1 form major component of lipoproteins which are known to be involved in the pathogenesis of atherosclerosis. ApoB/Apo A-1 ratio reflects the balance between atherogenic and anti atherogenic particles thus reflecting the net atherogenic risk in such subjects. Objectives:- To estimate serum Apo B and Apo A1 level and assess the role of their ratio apoB/apoA-1 as atherosclerosis risk predictor ofangiographically proven athrerosclerosis. Material and Methods:-Study population consisted of angiographically documented 50 cases with coronary artery atherosclerosis and 50 controls without atherosclerosis of coronary artery. Serum lipid profile was measured on SYNCHRON CX-9 using standard kits. Serum apolipoprotein A and B were measured by immunoturbidemetric method on SYNCHRON CX-9using kits from SENTINEL. Results:- Apo B/ Apo A1 ratio was significantly higher in cases than controls with p=0.008. No significant difference was found in conventional lipid markers of cases and controls. Conclusion:- Apo B/ apo A1 ratio is a better atherosclerosis risk predictor than conventional lipid markers in angiographically proven atherosclerosis.