SERUM CHEMERIN AS A PREDICTOR OF CORONARY ARTERY DISEASES IN TYPE 2 DIABETES

Chemerin is anadipokine that has attracted considerable interest due to an increasing body of evidence supporting its roles in adipogenesis, energy metabolism, and inflammation. Our objective was to determine the level of serum chemerin in type 2 diabetic (T2DM) patients and to evaluate its role as a predictor of coronary artery diseases (CAD)in these patients.This case control study was carried out on 30 T2DM patients without CAD, 30 T2DMpatients with CAD and 30 apparently healthy, age and sex matched subjects. CAD was diagnosed as presence of one or more coronary arteries with significant stenosis (?50%)and its severity was evaluated by Gensiniscore.All studied individuals were subjected to determination of fasting glucose, glycated hemoglobin, lipid profile, high sensitive c reactive protein (hsCRP) and serumchemerin.Our result revealed that serum chemerin was significantly increased in diabetic patients compared to controls and in diabetic patients with CAD compared to those without CAD. It was significantly correlated with hsCRP and Gensini score in CAD patients.Increasing chemerin was an independent predictor of CAD in T2DM.Receiver operating characteristic curve analysis of chemerin revealed anarea under curve of 0.949. At cut off value of >375 ng/L, chemerin had 96.7% sensitivity and 86.6% specificity in prediction of CAD in T2DM patients. In conclusion,serum chemerin was increased in type 2 diabetic patients and associated with CAD in these patients. Itwas correlated with disease severity and can be used in prediction of CAD in type 2 diabetic patients.