STUDY OF MALONDIALDEHYDE AS OXIDATIVE STRESS AND SUPEROXIDE DISMUTASE AS ENZYMATIC ANTIOXIDANT IN TYPE II DIABETES MELLITUS PATIENTS WITH AND WITHOUT PERIPHERAL NEURITIS.
- Internal medicine department, Faculty of Medicine, Al-Azhar and Zagazig University-Egypt.
- Clinical pathology department, Faculty of Medicine. Sanaa University –Yemen.
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Background:- Diabetic neuropathy is the most common complication of diabetes mellitus (DM). Poor glycemic control and long standing diabetes lead to diabetic complications. The cause of diabetic complications is the accumulation of diabetic stress factors and decrease of antioxidant stress factors. Oxidative stress, defined as a disturbance in the balance between the production of reactive oxygen species (free radicals) and antioxidant defenses, one of the most important intracellular antioxidant substances is an enzyme, superoxide dismutase which scavenges free radicals by converting the harmful superoxide ion into stable hydrogen peroxide. Aim of the work:- Evaluation of superoxide dismutase (SOD) as antioxidant factor and malondialdehyde (MDA) as oxidative stress factor in type II diabetes and its relation to control and duration of diabetes. Patients and methods:- 90 patients with type II diabetes were involved in this study, 50 patients with peripheral neuritis ( group I) and 40 patients without peripheral neuritis ( group II) in addition to 20 normal subjects as control (group III). All individuals were subjected to full history taking, full clinical examinations including examinations of peripheral nerves, measurement of blood sugar, HbA1c, serum lipids, superoxide dismutase (SOD) and serum malondialdehyde. Results:- the level of serum lipids, HbA1c, and serum malondialdehyde were significantly increased in patients with peripheral neuritis compared to the other groups. Superoxide dismutase was significantly decreased in peripheral neuritis patients compared to the other groups. Conclusion Long standing diabetes and poor glycemic control is associated with decreased serum superoxide dismutase and increased plasma malondialdehyde, which can be considered as markers for diabetic control and diabetic peripheral neuropathy complications in type II diabetes.
[Ahmed Mohamed Abohassan, Said M. Al-Barshomy and Sultan Ahmed Al-kobaty (2016); STUDY OF MALONDIALDEHYDE AS OXIDATIVE STRESS AND SUPEROXIDE DISMUTASE AS ENZYMATIC ANTIOXIDANT IN TYPE II DIABETES MELLITUS PATIENTS WITH AND WITHOUT PERIPHERAL NEURITIS. Int. J. of Adv. Res. 4 (Jun). 788-793] (ISSN 2320-5407). www.journalijar.com
