TO ASSESS THE FREQUENCY OF RAISED SERUM URIC ACID LEVEL IN PATIENTS WITH PSORIASIS AND COMPARE IT WITH HEALTHY CONTROLS IN OUTPATIENT OF A TERTIARY CARE HOSPITAL.

Objective of the study:- To assess the frequency of raised serum Uric acid level in patients with psoriasis. To compare the uric acid levels of patients with Psoriasis with control group. Introduction:- Hyperuricemia is a strong predictor or risk factor for Psoriasis but not a characteristic of Psoriasis. Further there is agreement on the turnover of the skin cells which could contribute to uric acid elevations in psoriasis patients. The prevalence of hyperuricemia is remarkably greater in psoriatic patients than in age-, sex-, and weight-matched control patients, and is independent of coexisting metabolic disorders. Very limited number of studies has been conducted in Pakistan this will give an insight into the problem as Psoriasis is common in Pakistan. Methods:- A case control study was conducted in OPD of a Dow University Hospital suffering from Psoriasis. During a year, by using non-probability convenient sampling only 100 subjects were eligible to enroll in the study after ensuring inclusion, exclusion criteria. Data Analysis was carried out by IBM SPSS statistics software 21.0. 100 healthy workers and subjects with no known association of uric acid metabolism and negative family history of Psoriasis enrolled as controls. A semi structured questionnaire was administered. Subjects with different psoriatic conditions enrolled to assess hyperuricemia while in control group subject with skin conditions other than Psoriasis or healthy people with different occupational background were enrolled Data analysis was done by SPSS version 21. Results:- Out of 100, 50% were females and 50% were males with psoriasis out of which and in control group 52% were males and 48% were females., time since subject has got psoriasis has variation but minimum recorded was 3 months and maximum was 18 years, 39 subjects reported positive family history ,subjects enrolled in the study with different psoriatic conditions have different sites of involvement like scalp, nail, joints, abdomen, knees, elbows, limbs etc specifically 47 subjects reported Nail Involvement, 23 subject reported Joint Involvement and 54 subject reported Scalp Involvement, 51 reported mild and 49 reported moderate BSA involvement. Conclusions:-Hyperuricemia is a common finding in psoriatic patients when it is being compared with healthy control. Its treatment might be clinically useful for the global treatment of patients. Patients with extensive involvement of the skin tended to have a higher incidence of hyperuricemia