THE RISK OF NULL- GLUTATHIONE S TRANSFERASE THETA 1 (GST-T1) POLYMORPHISM IN ESSENTIAL THROMBOCYTHAEMIA.

Introduction:-Essential thrombocythemia (ET) is a chronic myeloproliferative disorder (MPNs) that affectsprimarily the megakaryocytic cell line.Several studies have been published on the relationship between GSTT1 and various types of cancers. In this study and for the first time, we evaluated the association of GSTT1 polymorphism and the susceptibility ofessential thrombocythemia (ET) among Sudanese patient. Materials and methods:-A Total of 53 Sudanese patients from both gender diagnosed by ET according to World Health Organization (WHO) diagnostic criteria were recruited in this study after informed consent and ethical approval from Alneelain ethnical committee. On the other hand, 50 healthy volunteers were recruited as control group. EDTA blood sample was collected to determine the GSTT1 mutation, leukocytes count, platelets count and hemoglobin concentration for each patient. Result and conclusion:-In our study and for the first time, GSTT1-null genotype was found tobe more frequent in the controls than the cases, with OR 1.9 suggesting that, GSTT1-null genotype is a genetic risk factor ET.