COMPERATIVE STUDY OF NEEM, GARLIC, AND HENNA WITH ANTIBIOTIC NEBANOL® AGAINST ARTIFICIAL WOUND IN GUINEA PIGS.

Natural products are found to be more effective with least side effects as compared to commercial antibiotics so that reason alternated remedy are used for treatment of various infections. The aim of the present study was to evaluate the possible comparative efficacy of Neem (Azadirachta indica), Garlic (Allium sativum) and Henna (Lawsonia alba) with Antibiotic Nebanol (Neomycin Sulphate and Bacitracin Zinc) on artificially induced wound in 3cm length and 0.5 cm depth were made on the two thigh muscles an experimental model in Guinea pigs. The test animals were randomly chosen and divided into five groups having five Guinea pigs in each. Group-I, Group -II, Group -III received Neem leaf paste, Garlic paste, Henna paste and Group- IV received standard antibiotic Nebanol powder respectively. Group-V was kept as control and received vehicles only (distilled water containing 0.1% Tween-80). Neem leaf paste, Garlic paste, Henna paste, & Nebanol treatment reduced the wound within 12, 14, 17 & 13 days respectively. On the other hand, wound in control group was automatically reduced within 21 days. The present study showed that Neem was best effective among all & was found better than antibiotic Nebanol. It is concluded that among three preparations Neem may be used against skin wound because it is less expensive, easily available and having less side effect.