Applications of cyclodextrins: formation of inclusion complexes and their characterization

Cyclodextrins (CDs) act as host molecules to form inclusion complexes rather nonspecifically with a wide variety of guest molecules. These complexation favorites the high solubility of different molecules invites. Cyclodextrin complexation offered the possibility to improve the aqueous solubility of variety molecules and not modification of its original structure. In the present review of the literature was carried out to characterize the formation of inclusion complexes by different techniques in the solid and in the solution state complexation. The applications of cyclodextrins have been explained neatly and legibly. So it has wide applications in many industries, especially in the food and pharmaceutical industries. The characterization of inclusion complexes was done with a purpose to determine the interaction of different molecules with cyclodextrins which confirm the formation of inclusion complexes. Its inclusion complexes were identified by Thermo-Analytical Methods, Scanning Electron Microscopy (SEM), X-Ray diffractometry Single, Crystal X-Ray Structure Analysis, Infra-Red (IR) Spectroscopy, Thin Layer Chromatography (T L C). The Inclusion complexation in solution state characterized by Electrochemistry, Polarography, Conductivity Polarimetry Solubility Studies, Nuclear Magnetic Resonance (NMR) Spectroscopy, Electron Spin Resonance (ESR), Ultraviolet/Visible (UV/VIS) Spectroscopy, Fluorescence Spectroscopy, Circular Dichroism (CD) Spectroscopy, pH-Potentiometry Titration and Microcalorimetry.