The Possible Effects of Montelukast against Doxorubicin- Induced Nephrotoxicity in Rabbits
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Background Doxorubicin is a potent chemotherapy agent used to treat a broad spectrum of malignancies, but it has a significant nephrotoxicity which associated with increase generation of active metabolite and reactive oxygen radicals that damaged cells membranes through lipid peroxidation of kidney with decreased levels of antioxidants compounds. Objective: the present study aimed to evaluate the possible effects of montelukast against doxorubicin-induced nephrotoxicity in rabbits. Material &Methods: This study was carried out on eighteen rabbits of both sex weighing between 1000-1500 gm, they were equally divided into three groups: control group: received (5ml) of isotonic saline i.p. at day3.Doxorubicin group: treated with single dose of doxorubicin (25 mg/kg i.p.)at day 3. Montelukast prophylaxis and treatment group: treated with montelukast (10mg/kg oral) for 3 days before and two days after a single injection of doxorubicin. All animals were sacrificed at day 5. Changes in serum urea, creatinine, total protein and albumin were evaluated .In addition, glutathione and malondialdehyde of kidney tissues were measured. Finally histopathology changes scores of kidney for all groups were examined. Result: Doxorubicin administration resulted in a significant increment of serum urea and creatinine and kidney tissues malondialdehyde levels while significant reduction of serum levels of total protein and albumin and kidney tissues glutathione levels compared to that of control group. Histopathological changes scores showed a moderate score level compared to control group (P? 0.05). Montelukast prophylaxis and treatment group showed a significant elevation in serum urea and creatinine and kidney tissues malondialdehyde whereas a significant reduction in seum albumin and tissue glutathione in kidney tissue, at P ? 0.05. Conclusion: According to the results obtained from this study one can conclude the montelukast ability to potentiate doxorubicin nephrotoxicity.
[Haider F. Al-Saedi, Adeeb A. Al-Zubaidy, Yaurb I. Khattab (2014); The Possible Effects of Montelukast against Doxorubicin- Induced Nephrotoxicity in Rabbits Int. J. of Adv. Res. 2 (Nov). 0] (ISSN 2320-5407). www.journalijar.com
