12Nov 2018

ANTI ULCER ACTIVITY OF PRICKLY PEAR (OPUNTIA FICUS INDICA) CLADODES EXTRACTS.

  • Laboratoire Eco-conception, Energie Environnement et Innovation. Universit? Hassan I, Facult? des Sciences et Techniques, Settat, Maroc.
  • H?pital de proximit? de Roummani, D?l?gation de Khemissat, Maroc.
  • Centre hospitalier provincial Temara, D?l?gation de Skhirat-Temara, Maroc.
Crossref Cited-by Linking logo
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

The medicinal valorization of prickly pear has been evaluated by the survey of the anti-ulcer of the some functional compounds of the plant. The antiulcer activity has been valued, in vivo, on animal model whose ulceration has been provoked by ethanol. Resulted macroscopic and microscopic exams of the stomachs of rats, showed that the powder of cladodes as well as purified mucilage, possess a protective action against ulceration.When these compounds are administered at curative title, the organism doesn't manage to regenerate completely the damages provoked by the ethanol. These results have been confirmed besides by the survey of superoxide dismutase (SOD) activities, after purification. The SOD activities were normal among the rat?s witnesses and those treated by the excerpts at preventive title. On the other hand the ulcerous rats and those treated to preventive title present some SOD activities more elevated.

  1. Habibi Y., M. Mahrouz & M.R. Vignon: Arabinan-rich polysaccharides isolated and characterized from the endosperm of the seed of Opuntia ficus-indica prickly pear fruits. Carbohydr Polymers 60, 319-329 (2005)
  2. Retamal, N., Duran, J.M., and Fernandez, J. (1987): Seasonal variations of chemical composition in prikly pear (Opuntia ficus indica L. Mill.). J. Food Sci. Agric. 38: 303-311.
  3. Trachtenberg, S. and Mayer, A.M. (1981): Composition and properties of Opuntia ficus-indica. 20 (12): 1665-1668.
  4. Nobel, P.S., Cavelier, J. and Andrad, J. L. (1992): Mucilage in cacti: its apoplastic capacitance, associated solutes, and influence on tissue water relations. J. Exp. Bot. 43:641-648.
  5. Paulsen, B. S. and Lund, P. S. (1979): Water ? soluble polysaccharides of Opuntia ficus-indica cv. ?Burbank?s Spinless?. Phytochem. 18: 569-571.
  6. Periago, M. J., Ros, G., Lopez, G., Martinez, M. C. and Rincon,F. (1993)?: Componentes de la fibra diet?tica y sus efectos fisiologicos. Esp. Cienc. Technol. Aliment. 33, 3: 229-246.
  7. Maataoui, B. S. et Hilali, S. (2004): Anti-hyperglycemiant effect of mucilage from Opuntia ficus-indica. Metabolic Syndrome, type II Diabetes and Atherosclerosis Congress. Soci?t? Marocaine d?Ath?roscl?rose. Marrakech, Maroc.
  8. Ibanes, C. R. and Meckes, L.M. (1983): Effet of semi-purified product obtained from Opuntia streptacantha L. (a cactus) on glycemia and triglyceridemia of rabbit. J. Chromtogr. 913: 415-420.
  9. Cardenas, A., Higuera, C. I. and Goycoolea, F. (1997):? Rheology and agregation of cactus (Opuntia ficus indica) mucilage in solution. Professinal Ass. Cactus Dev. 2 : 152-159.
  10. B. S., Hmyene, A. et Hilali, S. (2005)?: Contribution ? la valorisation m?dicinale des compos?s fonctionnels d?Opuntia ficus-indica. Congr?s International sur les Plantes M?dicinales. Facult? des Science et Techniques, Errachidia, Maroc 2005.
  11. Park, E. H., Kahng, J. H. And Paek,E. A.(1998): Studies on the pharmacological action of cactus : identification of its anti- inflammatory effect. Arch. Pharm. Res., 21, 1: 30-34.
  12. Rosado, J. L. and Diaz, M. (1995) Physico - chemical properties related to gastrointestinal function of 6 sources of dietary fiber. Rev. Invest. Clin. 47, 4: 283-289.
  13. Lee, E.B., Hyan, J. E., Lida, W. and Moon, Y. I. (2002): Effet of Opuntia ficus-indica var. Saboten stem on gastric damages in rats. Arch. Pharm. 25, 1: 67-70.
  14. Meyer, N. B. and Melaughin J. L. (1981): Economic uses of Opuntia. Cactus and Succulent Journal 53: 107-112.
  15. Tomezyk, M., Zovko-Konci?,M. and Chrostek,L.Phytotherapy of alcolism. Nat.Prod.commun.7, 273-280.
  16. Tesoriere,L.,Attanzio,A.,Allegra,M., Gentile,C., and Livera,M.A. Indicaxanthin inhibits NDPH oxidase (NOX)-1 activation and NF-kB-dependent release of inflammatory mediators and the increase of epithelial permeability in IL-1B-exposed Caco-2 cells.Br.J.Nutr.111,415-423 (2014).
  17. Ahmad, A.; Davies, J.; Randall, S.; Skinner, G.R.B. 1996. Antiviral properties of extract of Opuntia streptacantha. Antivir. Res. 30: 75?85.
  18. Lee, J.-A.; Jung, B.-G.; Lee, B.-J. 2012. Inhibitory effects of Opuntia humifusa on 7, 12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13- acetate induced two-stage skin carcinogenesis. Asian Pac. J. Cancer Prev. 13, 4655?4660.
  19. Sijelmassi, A. Les plantes m?dicinales du Maroc. 4eme ?dition. Edition le Fennec. Casablanca, Maroc. 1996.
  20. B. Maataoui, A. Hmyene, S. Hilali, Activit? antiulc?reuse du mucilage extrait des raquettes du figuier de Barbarie (Opuntia ficus-indica). Cahier du Symposium Doctoral National, Biologie, Sant? et Environnement, 1 (2004): 117-120.
  21. E. Hodge, B. T. Hofreiter, Determination of reducing sugars and carbohydrates. ?M?thods in carbohydrate chemistry?. Edition Whistler et Wolform. Academic press, New york, USA. 1962.
  22. F. Delgado, A. R. Jimenes, L.O. Paredez, Natural pigments: Carotenoids, anthocyanins and betains ? characterisctics, Biosynthesis, processing and stability. Crit. Rev. Food Sci. Nutr. 40 (2000): 173-189
  23. J.?Magistretti, M. Conti, A.? Cristoni, Antiulcer activity of an anthocyanidin from vaccinum myrtillus. Arzneimittle Forschung Drug Research, 38 (1988): 686-690.
  24. M. Galati, S.? Pergolizzi, N.?Miceli, M. T. Monforte, M. M. Tripodo. Study on the increment of the production of gastreique mucus in rats treated with Opuntia ficus indica (L.) Mill. cladodes. Journal of Ethnopharmacology, 83 (2002): 229-233.
  25. G. Burkitt, B. Young, J. W. Heath, Histologie Fonctionnelle Wheater 3eme Edition. Paris 1993.
  26. Fridovich, Superoxide dismutase. [Review], Advances in Enzymologie and Related Areas of molecular Biology. 41 (1974): 35-97.
  27. H. Lowry, N. J. Rosenberg, A. L. Farr, R. J. Randal, Protein measurment with the Folin phenol reagent. J. Biol. Chem. 193 (1951): 265-275.
  28. Osatoni, Y. Masuda, K. Hara, T. Ishihara, Purification, N terminal of Cu ? Zn superoxide dismutase from japenes flounder (Paralichthys olivaceus) hepato-pencreas. Comp. Bioch. Physiol. Part B, 128 (2001) : 751-760.
  29. C. Stintzing, Cactus stems (Opuntia spp.): a review on their chemistry, technology, and uses. : Mol Nutr Food Res. 49 (2005) 2:175-94.
  30. Saenz, E. Sepulvida, Alternative de indistrualizacion de la tuna (Opuntia ficus indica). Alimentos. 18 (1993) 3: 29-32.
  31. Szabo, J. S Trier, A. Brown, J.? Schnoor, Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology. 88 (1985): 228-236
  32. L. Wallace, Mecanisme of protection and healing: current knowledge and future research. The American Journal of Medicin, 110 (2001) (8): 19S-23S.
  33. Saag, G. R Sanderson, P. Mona, G. Ramos, Cactacea mucilage composition. Journal of Agricultural Science. 26 (1975): 993-1000.
  34. Clarke, R. L. Anderson, B. A. Stone, From and function of arabinogalactans and arabinogalactan-proteins. Phytochemestry, 18 (1979): 521-540.
  35. Trachtenberg, A.M. Mayer, Biophysical property of Opuntia ficus-indica mucilage. Phytochemestry, 21 (1982): 2835-2843.
  36. M.? Galati, M. R. Mondello, D.?Giuffrida, G.? Dugo, N.? Miceli, M. F. Pergolizzi. Taviano, Chemical characterisation and biologie effects of sillician Opuntia ficus-indica (L.) Mill. Fruit juice: Antioxidant and antiulcerogenic activit?. J. Agric. Food Chem. 51(2003): 4903-4908.

[S. B. Maataoui, R. B. Maataoui, B. Almesrar and S. Hilali. (2018); ANTI ULCER ACTIVITY OF PRICKLY PEAR (OPUNTIA FICUS INDICA) CLADODES EXTRACTS. Int. J. of Adv. Res. 6 (Nov). 498-506] (ISSN 2320-5407). www.journalijar.com

S. B. MAATAOUI
Professeur

DOI:

Article DOI: 10.21474/IJAR01/8023      
DOI URL: https://dx.doi.org/10.21474/IJAR01/8023

Download Full Paper

Download PDF No. of Downloads: 95 | No. of Views: 380