26Feb 2018

EVALUATION OF THE LOCAL ANAESTHETIC EFFECT OF CRASSOCEPHALUM CREPIDIOIDES IN SUITABLE EXPERIMENTAL ANIMAL MODELS.

  • Post Graduate Trainee, Department of Pharmacology, RIMS, Imphal, Manipur.
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Objective: Crassocephalum crepidioides (Family: Asteraceae) is an errect, annual and succulent herb growing in many tropical regions. This plant has been used to treat indigestion, diarrhoea, headache and epilepsy by the local people. The leaves are heated and the succus is used for treating sores and fresh wounds since many years. Hence considering its use in treating wounds for many years by the local people in different parts of the world, an attempt has been made to evaluate the role of Crassocephalum crepidioides in local anaesthesia using suitable experimental animal models. Materials and methods: Methanol extract of Crassocephalum crepidioides was tested for local anaesthetic action by using the following models: (i) intracutaneous wheal in guinea pigs (ii) plexus anaesthesia in frogs. In both the models 0.9% normal saline was used as a control and 2% xylocaine was used as the standard drug. Results: The intracutaneous wheal method in guinea pigs showed 0.33% and 0.57% anaesthesia in test drug of concentrations of 10% and 20% respectively compared to 93.33% anaesthesia using the standard drug, xylocaine of 2% concentration (P<0.01). In the lumbar plexus anaesthesia method in frogs, the onset of local anaesthetic action was 5.12?0.14 and 2.09?0.12 min in the test and xylocaine treated groups respectively when compared to the control group where it was 18.13?0.29 min (P<0.001). Conclusion: The present study showed that Crassocephalum crepidioides has significant local anaesthetic property.

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[Ananya Das. (2018); EVALUATION OF THE LOCAL ANAESTHETIC EFFECT OF CRASSOCEPHALUM CREPIDIOIDES IN SUITABLE EXPERIMENTAL ANIMAL MODELS. Int. J. of Adv. Res. 6 (Feb). 1831-1834] (ISSN 2320-5407). www.journalijar.com

Ananya Das
Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, Manipur - 795004

DOI:

Article DOI: 10.21474/IJAR01/6624      
DOI URL: https://dx.doi.org/10.21474/IJAR01/6624

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