25Oct 2017

BIOMECHANICS OF LOW LEVEL LASER THERAPY: A REVIEW.

  • Department of oral pathology and microbiology, srm dental college,ramapuram.
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Low Level Laser Therapy (LLLT) is a unique method of laser delivery that affects biological systems through non-thermal means. The photobiological response is the result of photo activated chemical or physical changes produced by the absorption of non-ionizing electromagnetic radiation by a viable cell. Mitochondrial enzymes being the natural chromophore are the likely initial acceptors of photon molecules and upon activation of a cascade of enzymatic activity contribute to the beneficial biological effects of LLLT. This review throws light on the molecular mechanisms upon exposure of biological tissue to low level lasers and its effects on gene expression of the cells.

  1. Maiman TH. Stimulated optical radiation in Ruby. Nature 1960;187:493-94.
  2. Hamblin MR. Mechanisms of low level light therapy. Proc. of SPIE 2009; 6140: 614001-1.
  3. Posten W, Wrone DA, Dover JS, Arndt KA, Silapunt S, Alam M. Low-level laser therapy for wound healing: mechanism and efficacy.Dermatol Surg.?2005;31(3):334?40.
  4. Thiel H. Low power laser therapy?an introduction and a review of some biological effects. The Journal of the Canadian Chiropractic Association. 1986 Sep;30(3):133.
  5. Kovacs L, Varga L, Palyi I, et al. Experimental Investigation of photostimulation effect of low energy He Ne-laser radiation. Laser in Biomedical Research. 1973;4:14-16
  6. Wan S, Parrish JA, Anderson RR, et al. Transmittance of nonionizing radiation in human tissues. Photochemistry and Photobiology. 1981;34:679-68 1.
  7. Karu TL, Kalendo GS, Letokhov VS. Control of RNA synthesis rate in tumor cells HeLa by action of low-intensity visible light of copper laser. Lett Nuovo Cimento 1981;32:2:55-59
  8. Karu TL. Local pulsed healing of absorbing chromatophores as a possible primary echanism of low-power laser effect. In: Galletti G, Bolognani L, Laser Applications in Medicine and Surgery. 1992.
  9. Sun Y, Oberley LW. Redox regulation of transcriptional activators. Free Radic Biol Med 1996;21:335-48.
  10. Srinivasan S,? Avadhani? ? Cytochrome? c? oxidase? dysfunction in oxidative stress. Free Radic Biol Med 2012; 53(6): 1252-63.
  11. Karu TI, Kolyakov SF. Exact action spectra for cellular responses relevant to phototherapy. Photomed Laser Surg? 2005; 23(4):355-61.
  12. Yu W, Naim JO, McGowan M, Ippolito K,Lanzafame RJ. Photomodulation of oxidative metabolism and electron chain? enzymes in rat liver mitochondria, Photochem Photobiol 1997;66(6): 866-71.
  13. Passarella S. He-Ne laser irradiation of isolated mitochondria. J Photochem Photobiol 1989; 3(4): 642-3.
  14. Lane N. Cell biology: power games. Nature 2006;443(7114): 901-3.
  15. Borutaite V, Budriunaite A, Brown GC. Reversal of nitric oxide-, peroxynitrite- and S-nitrosothiol-induced inhibition of mitochondrial respiration or complex I activity by light and thiols. Biochim Biophys Acta 2000; 1459(2-3): 405-12.
  16. Karu T. Primary and secondary mechanisms of action of visible to near-IR radiation on cells. J Photochem Photobiol 1999; 49(1):1-17.
  17. Liu H, Colavitti R, Rovira II, Finkel T. Redox- dependent transcriptional regulation. Circ Res 2005; 97(10): 967-74.
  18. Zhang Y, Song S, Fong CC, Tsang CH, Yang Z,Yang M. cDNA Microarray Analysis of Gene Expression Profiles in Human Fibroblast Cells Irradiated with Red Light. Journal of Investigative Dermatology 2003; 120: 849?57.
  19. Clinical and experimental? applications? of? NIR-LED photobiomodulation, Photomed Laser Surg 24 (2006) 121-8.
  20. L. Liang,? H.T.? Whelan,? J.T.? Eells,? H.? Meng,? E. Buchmann,? A.? Lerch-Gaggl? and? M.? Wong-Riley,? Photobiomodulation? partially? rescues? visual? cortical neurons from cyanide-induced apoptosis,Neuroscience 139 (2006) 639-49.
  21. Asahi,? M.? Hoshimaru,? Y.? Uemura,? T.? Tokime,? M. Kojima, T. Ohtsuka, N. Matsuura, T. Aoki, K. Shibahara and? H.? Kikuchi,? Expression? of? interleukin-1? beta converting enzyme gene family and bcl-2 gene family in the rat brain following permanent occlusion of the middle cerebral artery, J Cereb Blood Flow Metab 17 (1997) 11-8.
  22. Lucas C, Criens-Poublon LJ, Cockrell CT, de Haan RJ. Wound healing in cell studies and animal model experiments by Low Level Laser Therapy; were clinical studies justified? A systematic review. Lasers in medical science. 2002 Jun 20;17(2):110-34.
  23. Byrnes KR, Barna L, Chenault VM, Waynant RW, Ilev IK, Longo L, Miracco C, Johnson B, Anders JJ. Photobiomodulation improves cutaneous wound healing in an animal model of type II diabetes. Photomedicine and Laser Therapy. 2004 Aug 1;22(4):281-90.
  24. Peplow PV, Chung TY, Baxter GD. Laser photobiomodulation of wound healing: a review of experimental studies in mouse and rat animal models. Photomedicine and laser surgery. 2010 Jun 1;28(3):291-325.
  25. Hagen T, Taylor CT, Lam F, Moncada S. Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1α. Science. 2003 Dec 12;302(5652):1975-8.
  26. Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nature medicine. 2003 Jun 1;9(6):669-76.
  27. Zhang Y, Song S, Fong CC, Tsang CH, Yang Z,Yang M. cDNA Microarray Analysis of Gene Expression Profiles in? Human Fibroblast Cells Irradiated with Red Light. Journal? of Investigative Dermatology 2003; 120: 849?57.

[Arulmozhi Nandakumar, Nandhini Guna, Vidya Hari Iyer And A. Ramesh Kumar. (2017); BIOMECHANICS OF LOW LEVEL LASER THERAPY: A REVIEW. Int. J. of Adv. Res. 5 (Oct). 1662-1665] (ISSN 2320-5407). www.journalijar.com

Arulmozhi Nandakumar
SRM DENTAL COLLEGE,RAMAPURAM, CHENNAI

DOI:

Article DOI: 10.21474/IJAR01/5685      
DOI URL: http://dx.doi.org/10.21474/IJAR01/5685

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