TWO CASES OF UNUSUAL LOCATIONS OF VENOUS THROMBOEMBOLISM, DUE TO FACTOR VIII EXCESS.

The genesis of venous thrombosis is multifactorial, requiring an etiological assessment, when the usual risk factors are absent. Thrombophilia can then be a frequent, acquired or congenital cause and becomes responsible for a state of hypercoagulability. The excess in antihemophilic factor A or factor VIII is part of the hereditary etiologies, which are not systematically sought in the case of unexplained thrombosis. This is due to its rarity compared to other more frequent causes (deficiency of protein C, protein S and antithrombin). At the Avicenne hospital in Marrakech, we received 2 women with thromboses of rare localizations: renal and cerebral. Classical etiological investigations had not revealed the cause. Only the dosage of the factor showed significantly increased levels, apart from any physiological or pathological situations that could explain it, thus making the singularity of these two observations. Although treatment with the acute phase is well codified, the maintenance of anticoagulation in the long term remains questionable.