ONE CASE OF MANIFESTATION TROMBOTIC MICROANGIOPATHY.

Purpose: Presentation of one case of HUS. Shiga-like toxin producing E coli hemolytic-uremic syndrome (STEC-HUS) is a disorder that most often occurs when an infection in the digestive system produces toxic substances. These substances destroy red blood cells and cause kidney injury. Hemolytic-uremic syndrome (HUS) often occurs after a gastrointestinal infection with E .coli bacteria (Escherichia coli O157:H7). However, the condition has also been linked to other gastrointestinal infections andnongastrointestinal infections. atypical HUS(aHUS )is not infection-related. It is similar to another disease called thrombotic thrombocytopenic purpura TTP/TMA(tromboticmicroangiopathy)and is related to other diseases,lik lupus erythematosus ,antiphospholipidsyndrome.Haemolytic‐uraemic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are two clinically similar disorders characterized by severe microangiopathic haemolytic anaemia and thrombocytopenia. Thus, the two disorders are often difficult to distinguish. We presented case discussion of 32 old wumen with bloody diarrhea,oligoanuria and changes of awareness. Rezults: Increased level of LDH,creatinine, urea. Decreased level of ADAMTS 13. Anisocytosis, shisocytosis ,poikilocytosis .Renal biopsy revield global sclerotic changes, In CSF was found HSV1 virus, After treatment patient state was improved .motor and sensoric activation was increazed. Spontan breathing parameters improuved. Later Patient state was worsened despite of suitable treatment developed pulmonary embolizm and inferior vena cava embolizm . Conclusion: In patients with HUS , the fraquency of mortality is high, clinical manifestation also is nontypical.Adequite estimations of clinical signs in premorbid period and examination of organ function after hospitalization,prevention and management of complications gives a real chance of convalescence