30Sep 2017

INVOLVEMENT OF MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 IN BREAST TUMORIGENESIS.

  • Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, 190011, Srinagar, Jammu and Kashmir, India.
  • Department of Biotechnology, University of Kashmir, 190006, Srinagar, Jammu and Kashmir, India.
  • Department of Surgery, Shri Maharaja Hari Singh Hospital, 190011, Srinagar, Jammu and Kashmir, India.
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MKK6 expression analysis has been reported in various primary tumors, like esophagus, stomach, colon and prostate cancers but its significance in primary breast tumor patients remains unclear. We investigated the expression of MKK6 in cancer tissues through immunoblotting and immunofluorescence techniques in 25 resected cases of human breast carcinomas. Increased MKK6 protein expression was observed in 56% (14 ? 25) of breast cancer cases. These results indicate that the upregulated expression of MKK6 in cancer tissues has significant role in tumor progression and the clinical prognosis of patients with primary breast carcinoma.

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[Rafia A. Baba, Umar Mushtaq, Arif A. Parray, Deeba Kirmani, Lateef A. Wani and Firdous A. Khanday. (2017); INVOLVEMENT OF MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 IN BREAST TUMORIGENESIS. Int. J. of Adv. Res. 5 (Sep). 1626-1630] (ISSN 2320-5407). www.journalijar.com

Firdous A. Khanday
Department of Biotechnology, University of Kashmir, 190006, Srinagar, Jammu and Kashmir, India.

DOI:

Article DOI: 10.21474/IJAR01/5486      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5486

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