28Jul 2017

HEPATOPROTECTIVE PROPERTY OF SCHUMANNIANTHUS VIRGATUS (ROXB.)ROLFE AGAINST D-GALACTOSAMINE INDUCED HEPATOTOXICITY IN WISTAR RATS.

  • Ethnomedicine and Ethnopharmacology Division, Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram, 695562, India.
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The rhizomic extract of Schumannianthus virgatus Roxb.)Rolfe is used by Kani tribe of Kerala to treat liver disorders. In the present study, the potential effectiveness of crude and ethanolic extract of Schumannianthus virgatus on D-galactosamine induced hepatotoxicity was evaluated. Pretreatment with crude (SV) and ethanolic extract (SVEF) significantly attenuated the elevation in biochemical parameters, such as alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase(ALP) ,total bilirubin and the malondialdehyde concentrations in liver tissue. Pretreatment with SV and SVEF significantly restored the reduction of catalase activity and glutathione (GSH) content. The histopathalogical studies also supported the protective effect of the extract. The overall data indicated that Schumannianthus virgatus possesses hepato protective effect against D-GalN induced hepatic damage, and the main mechanism involved in the protection could be associated with its strong capability to reduce the intracellular level of reactive oxygen species by enhancing the level of both enzymatic and non-enzymatic antioxidants .

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[V .Neethu. P .G. Latha , S. R. Suja, V .Vilash, R. Ragesh, S.Shoumya and A. L. Aneesh Kumar. (2017); HEPATOPROTECTIVE PROPERTY OF SCHUMANNIANTHUS VIRGATUS (ROXB.)ROLFE AGAINST D-GALACTOSAMINE INDUCED HEPATOTOXICITY IN WISTAR RATS. Int. J. of Adv. Res. 5 (Jul). 2301-2307] (ISSN 2320-5407). www.journalijar.com

NEETHU VISWANATH
JNTBGRI,Palode,Trivandrum,Kerala

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Article DOI: 10.21474/IJAR01/4976      
DOI URL: http://dx.doi.org/10.21474/IJAR01/4976

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