26May 2017

GENETIC BACKGROUND IN INITIATION, PROGRESSION AND TREATMENT OF PERIODONTAL DISEASES ? A REVIEW

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Periodontitis is a complex chronic inflammatory disease that results in the loss of connective tissue and alveolar bone support of the teeth. With increase in knowledge, the etiology of periodontal diseases is becoming more complex. A pathogenic micro flora is the causative agent for the initiation of periodontitis, which is often promoted by a poor oral hygiene and smoking, which both contribute strongly to the disease risk. Apart from the environmental factors, formal genetic studies have demonstrated the genetic basis of periodontitis and indicated that about half of the population variance in chronic periodontitis can be attributed to genetic factors. Thus it is now widely accepted that these differences among individuals who are at risk for the development of most diseases have a substantial inherited component. This complex combination of variables determines if and when a disease affects the person, how fast and how severely symptoms of the disease progress. Not only the initiation and progression of the disease, genetics also determines how the person responds to different treatments in terms of both side effects and the success of alternative therapies as pharmacogenomics which helps in individualizing the treatment.

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[Raga Bindu. J, VidyaSagar. S, Raja Babu. P, Satyanarayana. D and Srinivas. M. (2017); GENETIC BACKGROUND IN INITIATION, PROGRESSION AND TREATMENT OF PERIODONTAL DISEASES ? A REVIEW Int. J. of Adv. Res. 5 (May). 1052-1062] (ISSN 2320-5407). www.journalijar.com

Raga Bindu. J
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Article DOI: 10.21474/IJAR01/4215      
DOI URL: http://dx.doi.org/10.21474/IJAR01/4215

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