30Mar 2017

CORRELATION OF ALT/AST RATIO WITH INSULIN RESISTANCE IN METABOLIC SYNDROME.

  • Ramya SG-Junior Resident, Department of General Medicine, Lady Hardinge Medical College, Newdelhi.
  • Rajinder K Dhamija – Professor, Department of General Medicine, Lady Hardinge Medical College, Newdelhi.
  • Anil Gurtoo –Professor, Department of General Medicine, Lady Hardinge Medical College, Newdelhi.
  • Ritu Singh – Professor, Department of Biochemistry, Lady Hardinge Medical College, Newdelhi.
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Background:In recent years, non-alcoholic fatty liver disease is considered as a novel component of insulin resistance and metabolic syndrome, which is found to be associated with mild elevation of liver enzymes. Aim of the Study:The aim of this study was to correlate the ALT/AST ratio with insulin resistance calculated by HOMA-IR (Homeostatic model assessment-Insulin resistance) method among patients found to have metabolic syndrome. Design and Methodology: This was an observational cross sectional study which included 60 subjects of metabolic syndrome defined by International Diabetes Federation criteria. The relevant clinical examination and basic investigations were done. Fasting insulin levels were analysed by chemiluminescence method. Liver function tests were done by fully automated AnalyzerSynchron CX-9 using Roche kits, calibrators and Randox control Sera. Data was processed and analyzed by SPSS version 17.0 software. The Correlation between ALT/AST ratio and HOMA-IR was assessed using The Pearson correlation test. Results The ALT/AST Ratio was found to have positive correlation with HOMA-IR (Pearson’s correlation coefficient is +0.742 and the significance was <0.001). This study shows that ALT/AST ratio can be used as screening tool of insulin resistance in the community.

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[Ramya SG , Rajinder K Dhamija, Anil Gurtoo and Ritu Singh. (2017); CORRELATION OF ALT/AST RATIO WITH INSULIN RESISTANCE IN METABOLIC SYNDROME. Int. J. of Adv. Res. 5 (Mar). 1677-1684] (ISSN 2320-5407). www.journalijar.com

Ramya SG

DOI:

Article DOI: 10.21474/IJAR01/3678      
DOI URL: https://dx.doi.org/10.21474/IJAR01/3678

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