27Feb 2017

HISTOPATHOLOGICAL SPECTRUM OF SALIVARY GLAND TUMOURS. A HOSPITAL BASED STUDY.

  • Senior resident Post graduate department of Pathology Gmc Srinagar.
  • Senior resident Post graduate department of Obstetrics and GynaecologyGmc Srinagar.
  • Post graduate scholar post graduate department of pathology Gmc Srinagar.
  • Head of Department post graduate department of pathology Gmc Srinagar. 190010.
Crossref Cited-by Linking logo
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Background: Salivary gland tumors are common neoplasms of head and neck region. These tumors are complex andsome of them exhibit great deal of morphologic overlap .The majority of these neoplasms are benign. These tumours can occur in both major and minor salivary glands. 80% of major salivary gland tumoursoccur in the parotid glands, while most minor salivary tumours are located in the palate. As a general rule in clinical practice, the smaller the salivary gland is, the more likely the tumouris malignant. Objective: This study was carried out to study the histopathological spectrum of salivary gland tumors and to know their pattern of distribution. Material and Methods:-This is a two year retrospective study which was conducted in the Post graduate department of pathology Government Medical College Srinagar from January 2015 to December 2016 . Post surgical specimens were studied in detail to know the histological patterns. In each patient, age, sex, site and histopathological diagnosis was seen from record section of the department. The histological diagnosis of each individual tumor was based on the 2005 WHO classification of salivary gland tumors. Results:- During two year ( from January 2015 to December 2016), 100 cases of salivary gland tumors were diagnosed with peak incidence in third to fourth decade (48%).Among these, 63(63%) cases were benign and 31(31%) cases were malignant. The commonest site was parotid gland (68%) followed by submandibular glands(19%) and minor salivary gland tumors were 13%. Among benign tumours of salivary glands pleomorphic adenoma (42%) was most common followed by Warthintumour (12%),basal cell adenoma (7%) andMyoepithelioma (2%) and among malignant tumours,Mucoepidermoid carcinoma (46%) was most common followed by Adenoid cystic carcinoma (32.5%), Carcinoma ex pleomorphic adenoma (10.8%), Acinic cell carcinoma and Polymorphous low grade adenocarcinoma each comprising of (5.4%). Conclusion: Histopathological study of salivary gland lesions is the most important method in establishing the final diagnosis and accordingly guides in the specific management.


  1. Pons-Vicente O, Almendros-Marques N,Berini-Aytes L, Gay Escoda C. Minorsalivary gland tumors:Aclinicopathological study of 18 cases. Med Oral Pathol Oral CirBucal2008; 13:582-8.
  2. Ethunandan M, Davies B, Pratt CA, Puxeddu R, Brennan PA. Primary epithelial submandibular salivary gland tumors— Review of management in a district general hospital setting. Oral Oncol2009;45:173-6.
  3. Spiro 2001 JD,SpiroRH,Salivarytumors, InShahJP,DeckerSBC,ed;Cancer of the head & neck:2001;240- 250 .
  4. Eveson JW, Cawson RA. Salivary gland A review of  2410 cases with particular reference to histological types, site, age and sex distribution. J Pathol., 1985; 146: 51-8.
  5. Auclair PL, Ellis GL, Gnepp DR, Wenig BN, Janey CG. Salivary gland neoplasms: general considerations. In: Ellis GL, Auclair PL, Gnepp DR, editors. Surgical pathology of the salivary glands. Philadelphia: WB Saunders; 1991, p. 135-64.
  6. Nagler RM, Laufer D. Tumors of the major and minor salivary glands: review of 25 years of experience. Anticancer Res., 1997; 17: 701-7.
  7. Pinkston JA, Cole P. Incidence rates of salivary gland tumors: results from a population-based study. Otolaryngol Head Neck Surg., 1999; 120: 834-40.
  8. Yu GY, Ma DQ. Carcinoma of the salivary gland: a clinicopathologic study of 405 cases. SeminSurgOncol., 1987; 3: 240-4.
  9. Pires FR, Almeida OP, de Araujo VC, Kowalski LP. Prognostic factors in head and neck mucoepidermoid carcinoma. Arch Otolaryngol Head Neck Surg., 2004; 130: 174-80.
  10. Rosai, J. 2011. major and minor salivary glands. :Rosai and Ackerman’s Surgical Pathology. 10th Edn.; Mosby: An Imprint of Elsevier, Missouri, pp 817- 840.
  11. AbraAM,CornynJ,Scofield HH, Hansen Acinic cell adenocarcinoma  of the major salivary glands.Aclinicopathological study of 77 cases.Cancer 1965,18: 1145-1162.
  12. Nepal A, Chettri ST, Joshi RR, Bhattarai M, Ghimire A, Karki S; Primary Salivary Gland Tumors in Eastern Nepal Tertiary Care Hospital; J Nepal Health Res Counc 2010;8:31-4.
  13. Naeem Sultan Ali, Ahmad Nawaz, Shaheryar Rajput, MubasherIkram. Parotidectomy: A Review of 112 Patients Treated at a Teaching Hospital in Pakistan; Asian Pacific Journal of Cancer Prevention 2010;11.
  14. SaedeAtarbashiMoghadam, FazeleAtarbashiMoghadam, Mehdi Dadfar. Epithelial Salivary Gland Tumors in Ahvaz, Southwest of Iran; J Dent Res Dent Clin Dent Prospect 2010; 4:120-23.
  15. Satko I, Stanko P, Longauerova I. Salivary gland tumors treated in the stomatological clinics in Bratislava. J Craniomaxillofac Surg., 2000; 28: 56-61.
  16. Rahrotaban S, Masoomi P, Moradi M, et al. Frequency of salivary gland tumors in two referral center of Qazvin university of Medical sciences from 1999-2009. J Res Dent Sci., 2009; 2: 27-31.
  17. Lima SS, Soares AF, de Amoriom RF, et al. Epidemiologic profile of Salivary gland tumors: analysis of 245 cases. Braz J Otorrinolaringol., 2005; 71: 335-40.
  18. Luukkaa H, Klemi P, Leivo I, et al. Salivary gland cancer in Finland 1991-96: an evaluation of 237 cases. ActaOtolaryngol., 2005; 125: 207-14.
  19. Ahmad S, Lateef M, Ahmad R. Clinicopathological study of primary salivary gland tumors in Kashmir. JK Practitioner 2002; 9(4):231- 233.
  20. Mohammed Ayub M, Zahid S, Abbas Z and Shoukat M. Morphological pattern of parotid tumors. Journal of the College of Physicians and Surgeons 2008; 18(5):274- 277.
  21. Iqbal MS, Tabassum A, Chatura. K R, Malkappa S K, Basavaraja P K. Histomorphological study of salivary gland neoplasms: a 2 year study. Journal of Evolution of Medical and Dental Sciences,2013, Jan;2(4):315-324.
  22. Pablo Agustin Vargas, Rene Gerhard, Vergilius JF AraijoFalho and Ines Vieiro de Castro. Salivary gland tumors in Brazilian population: A retrospective study of 124 cases. Rev Hos ClinFac Med S Paulo 2002; 57(6):271-276.
  23. Rewusuwan S, Settakorn J, Mahanupab P, Salivary gland tumors in MaharajNakorn Chiang Mai hospital: A retrospective study of 198 cases. Chiang Mai Med Bull 2006; 45(2):45-43.
  24. Bashir S, Mustafa F, Malla H A, Khan A H, Rasool M, Sharma S. Histopathological Spectrum of Salivary Gland Tumors: A 10 Year Experience. Sch. J. App. Med. Sci., 2013; 1(6):1070-1074.
  25. Potdar GG, Paymaster JC. Tumors of salivary glands. Am J Surg 1969;118:440.
  26. Deepak Soni,KusumMathur et al .Histopathological spectrum of salivary gland lesions in tertiary care centre.Int J Med Res Prof 2016;2(2);209-15.
  27. BhavaniK,Urs RAN et al.Histopathological study of Salivary gland tumours.J.Evolution Med.Dent.Sci.2016; 5(72) : 5240-5244.
  28. Pablo Agustin Vergas, Rene Gerhard, Vergilius J. F. AraujoFiliho and Ines Vieira de Castro; Salivary gland tumors in Brazillian population: A retrospective study of 124 cases;Rev. Hosp. Clin. Fac. Med. S. PAULO 2002; 57(6):271-276.
  29. Thomas K M, Hutt M S R and Borgestein J. Salivary gland tumors in Malawi. Cancer 1980; 46:2328-2334.
  30. Richardson GS, Dickason WL, Gaisford JC, et al. Tumors of salivary glands; An analysis of 752 cases. Plastic ReconstrSurg 1975;55:131.

[Syed Imtiyaz Hussain, Gulshan Akhter, Farooq Sideeq, Baba Iqbal, Ruby Reshi, Farzana Manzoor and Arshi Beg. (2017); HISTOPATHOLOGICAL SPECTRUM OF SALIVARY GLAND TUMOURS. A HOSPITAL BASED STUDY. Int. J. of Adv. Res. 5 (Feb). 1912-1922] (ISSN 2320-5407). www.journalijar.com


Syed Imtiyaz Hussain
Senior resident Post graduate department of Pathology Gmc Srinagar.

DOI:


Article DOI: 10.21474/IJAR01/3361      
DOI URL: http://dx.doi.org/10.21474/IJAR01/3361