21Feb 2017

HEPATITIS E VIRUS IN RENAL TRANSPLANT RECIPIENTS.

  • Department of Medical Microbiology & Immunology, Faculty of Medicine, Alexandria University, Egypt.
  • Department of Microbiology & Immunology, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt.
  • Department of Internal Medicine; Faculty of Medicine, Alexandria University, Egypt.
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Hepatitis E virus is claimed to represent the most frequent cause of acute hepatitis and jaundice all over the world. In 2008, HEV was reported possibly to be responsible for chronic infection in immunosuppressed patients such as organ transplant recipients. This study aims at detection of HEV RNA and HEV IgM and IgG antibodies in sera of renal transplant Egyptian patients compared to apparently healthy control group of matched age and sex. The present study was carried out on sixty renal transplant patients recruited from the Transplantation Unit at Alexandria Main University Hospital and sixty apparently healthy control subjects. Sera of all cases and controls have been subjected to Real Time PCR for detection of HEV RNA and qualitative ELISA determination of HEV IgM and IgG Anti HEV IgG was positive in 56.7% of cases (34 out of 60) and in 75% of control subjects (45out of 60). HEV RNA was detected in 2 cases (3.3%) among renal transplant recipients, while the sixty control subjects were all negative. There is a high seroprevalance of HEV IgG among both patients and controls. The statistically insignificant lower prevelance among transplanted patients might be justified by intake of immunosuppressive drugs. Transplant recipients showed higher rate of HEV RNA positivity. The impact of immunosuppression on rate of viral clearance among such category of patients needs to be noted.

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[Malak A Aboukhatwa, Nesrine F Hanafi, Sarah M Abdelhamid, Yasmine S Naga and Sahar M Abdelfatah. (2017); HEPATITIS E VIRUS IN RENAL TRANSPLANT RECIPIENTS. Int. J. of Adv. Res. 5 (Feb). 1062-1066] (ISSN 2320-5407). www.journalijar.com

Sarah Magdy Abdelhamid
Faculty of Pharmacy, Damanhour University, Gomhoreya st, Damanhour, Egypt

DOI:

Article DOI: 10.21474/IJAR01/3252      
DOI URL: https://dx.doi.org/10.21474/IJAR01/3252

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