31Jan 2017

POTENTIAL TARGETS FOR ANTI-INFLAMMATORY AND ANTICANCER ACTIVITIES OF MARINE ALGAE GELIDIUM SESQUIPEDALE AND LAMINARIA OCHROLEUCA

  • Laboratory of Marine Biotechnology and Environment, Faculty of Science, University Chouaib Doukkali, BP 20, El Jadida, Morocco.
  • University Sidi Mohamed Ben Abdellah, BP 2202, Fez-Morocco.
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Marine algae are a source of compound endowed with ingenious structure and potential biological activities. In this study, extracts of red marine algae Gelidium sesquipedaleand brown marine algaeLaminaria ochroleuca, harvested from the coast of El Jadida-Morocco were investigated for their anti-inflammatory activity against phospholipase A2 and Elastase and for their cytotoxic activity using the test of brine shrimp lethality for larvae and then both algae were tested on KB cell lines (human buccal epidermal carcinoma), K562 cell lines (Human chronic myelocytic leukemia) and HeLa cell lines (human epitheloid cervix carcinoma?). For anti-inflammatory activity, both algae showed anti-elastase activity higher than 80%, however, only Gelidium sesquipedale showed a total inhibition of phospholipase A2 activity.Gelidium sesquipedale showed an anticancer activity against all cells lines used, however, Laminaria ochroleucashowed significant cytotoxic activity of 100% inhibition against Artemia salinaand an antitumor activity against KB cells lines.

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[Nabila Boujaber, Khadija Oumaskour, Fatima Lakhdar, Omar Assobhei and Samira Etahiri. (2017); POTENTIAL TARGETS FOR ANTI-INFLAMMATORY AND ANTICANCER ACTIVITIES OF MARINE ALGAE GELIDIUM SESQUIPEDALE AND LAMINARIA OCHROLEUCA Int. J. of Adv. Res. 5 (Jan). 2302-2309] (ISSN 2320-5407). www.journalijar.com

Boujaber Nabila
Laboratory of Marine Biotechnology and Environment, Faculty of Science, University Chouaib Doukkali, BP 20, El Jadida, Morocco

DOI:

Article DOI: 10.21474/IJAR01/3012      
DOI URL: http://dx.doi.org/10.21474/IJAR01/3012

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