30Jan 2017

RESVERATROL AS AN ALTERNATIVE TO REGULAR BLOOD TRANSFUSION- A NEW FETAL HAEMOGLOBIN INDUCER FROM NATURAL WORLD

  • Department of Genetics, Institute of Genetic Medicine and Genomic Science. 30A Thakurhat Road. Kolkata- 700128, West Bengal, India.
  • Department of Genetics, Institute of Genetic Engineering. 30 Thakurhat Road. Kolkata- 700128, West Bengal India.
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Recent molecular studies of fetal hemoglobin (HbF) regulation have shown promise for the development of clinical HbF inducers to be used in patients with β-thalassemia and sickle cell disease. However, while numerous promising inducers of HbF, have been studied at past in β-thalassemia patient with limited success resulted no universally effective agents. Increased production of fetal hemoglobin (HbF) can ameliorate the severity of both β-thalassemia and sickle cell disease (SCD), the major disorders of β-hemoglobin. The defective production of the β-globin molecule in patients with β-thalassemia can be compensated for by an increase in the production of the β-like globin molecule, γ-globin, which pairs together with α-globin chains to form HbF. Here we examined the clinical studies of one HbF inducer Trans-Resveratrol and found Complete Response (52.2%), Partial Response (18.2%) and Non response (15.9%) in patients who, after more than one year of treatment, remained at the different level of transfusion dependency with extended transfusion intervals. The present study is to provide a resource that will be valuable for the design of future studies of HbF inducers in β-thalassemia. According to our knowledge and literature review, probably this could be the first report for resveratrol clinical trial in eastern Indian population.

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[Anirban Roy Chowdhury, Puspal De, Sudipa Chakravarty and Amit Chakravarty. (2017); RESVERATROL AS AN ALTERNATIVE TO REGULAR BLOOD TRANSFUSION- A NEW FETAL HAEMOGLOBIN INDUCER FROM NATURAL WORLD Int. J. of Adv. Res. 5 (Jan). 1816-1821] (ISSN 2320-5407). www.journalijar.com

Puspal De
Institute of Genetic Engineering

DOI:

Article DOI: 10.21474/IJAR01/2950      
DOI URL: https://dx.doi.org/10.21474/IJAR01/2950

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