ANTIMICROBIAL DIHYDROFLAVONOL FROM SUDANESE CROTON ZAMBESICUS MUELL. ARG.(EUPHORBIACEAE) SEEDS
- Sudan University of Science and Technology, Faculty of Science, Dept. of Chemistry.
- Omdurman Islamic University, Faculty of Education.
- Alzaeem Al-Azhari University, Faculty of Education
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Information on the constituents of the Sudanese material of Croton zambesicus is scarce. Hence this study was designed to investigate the flavonoids of this versatile species and to evaluate its antimicrobial potential in an attempt to establish a rationale for its ethno-medical use. Preliminary phytochemical screening for secondary metabolites revealed the presence of flavonoids, saponins, alkaloids, steroids and tannins in ethanolic extract of Croton Zambesicus seeds. A dihydroflavonol was isolated from the seed extract. The isolate was purified by paper chromatography and identified via a combination of spectral tools (IR, UV, 1HNMR and mass spectroscopy). The isolated compound and the ethanolic extract were evaluated for antimicrobial activity against six standard human pathogens (Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Aspergillas niger, candida albicans), and significant results were obtained.
[Abdel Karim. M. , Nosiba. K. , Fath El-Rahman. A. and Suad. A. (2016); ANTIMICROBIAL DIHYDROFLAVONOL FROM SUDANESE CROTON ZAMBESICUS MUELL. ARG.(EUPHORBIACEAE) SEEDS Int. J. of Adv. Res. 4 (Sep). 1779-1785] (ISSN 2320-5407). www.journalijar.com
